Omega Program

The brainchild of Imperial Psi-Scientist Dr. Shinji Shimada, the "Omega Program" is based on his controversially groundbreaking latent Psionic evolution thesis and was held on a specialised facility, the Shiro Sanitarium, which gave birth to nightmarish psionic superweapons: the Psionic Decimator and Yuriko Omega and Izumi Matsui.

Emphasis on "controversially": the Omega Program has severely dehumanized Yuriko and Izumi, leading to the uprising of the former and the death of the latter - and Shimada himself - after the Real WWIII.